SLCO1B1 P155T - GET-Evidence

Note: This variant has not been sufficiently evaluated by a GET-Evidence editor.

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(SLCO1B1 Pro155Thr)

Short summary


Variant evidence
Computational 2

Variant Effect Predictor (Ensembl ):
Mutation Tasting Prediction: Polymorphism p value: 0.749803; protein features (might be) affected.
SIFT: Affect protein function 0.04
GVGD: GV 73.35; GD 28.88; Class C0
Multi-alignment of Q9Y6L6.2 solute carrier organic anion transporter family member 1B1 [Homo sapiens] with; XP_520785.2 [Pan troglodytes] XP_003265630.1 [Nomascus leucogenys] XP_001097704.1 [Macaca mulatta] XP_003265628.1 [Nomascus leucogenys] AAV53935.1[Macaca fascicularis] NP_001028113.1 [Macaca mulatta] XP_002752143.1 [Callithrix jacchus] XP_001498086.1 [Equus caballus] XP_002926619.1 [Ailuropoda melanoleuca] XP_002712675.1 [Oryctolagus cuniculus]

Functional -
Case/Control -
Familial -
Clinical importance
Severity -
Treatability -
Penetrance -


Insufficiently evaluated pharmacogenetic

(The "insufficiently evaluated" qualifier is assigned automatically based on the above evidence and importance scores.)

Inheritance pattern


Summary of published research, and additional commentary


Allele frequency

  • A @ chr12:21329813: 13.5% (1451/10732) in EVS
  • A @ chr12:21221079: 11.7% (15/128) in GET-Evidence
  • Frequency shown in summary reports: 13.5% (1451/10732)


Couvert P, Giral P, Dejager S, Gu J, Huby T, Chapman MJ, Bruckert E, CarriƩ A. Association between a frequent allele of the gene encoding OATP1B1 and enhanced LDL-lowering response to fluvastatin therapy. Pharmacogenomics. 2008 Sep;9(9):1217-27. PubMed PMID: 18781850.



hu04FD18 - CGI sample GS00253-DNA_F01_200_37
het A @ chr12:21329813


hu241DEA - CGI sample GS01175-DNA_D05 from PGP sample 1205491
het A @ chr12:21329813



hu3CAB43 - CGI sample GS01175-DNA_D03 from PGP sample 27486199
het A @ chr12:21329813


hu43860C - CGI sample GS00253-DNA_A01_200_37
het A @ chr12:21329813


hu44DCFF - CGI sample GS01669-DNA_C07 from PGP sample 74521372
het A @ chr12:21329813


hu4CA5B9 - CGI sample GS01669-DNA_B03 from PGP sample 14427241
het A @ chr12:21329813


hu604D39 - CGI sample GS00253-DNA_B02_200_37
het A @ chr12:21329813



hu72A81D - CGI sample GS01173-DNA_C02 from PGP sample 10366372
het A @ chr12:21329813


hu7A4AD1 - CGI sample GS01669-DNA_C05 from PGP sample 42408046
het A @ chr12:21329813


hu9385BA - CGI sample GS00253-DNA_E01_200_37
het A @ chr12:21329813


huA0E089 - CGI sample GS01175-DNA_B04 from PGP sample 88590671
hom A @ chr12:21329813


huBAAC98 - CGI sample GS01173-DNA_F02 from PGP sample 70008981
het A @ chr12:21329813


huD37D14 - CGI sample GS01175-DNA_A04 from PGP sample 13272228
het A @ chr12:21329813


GS06985 - var-GS06985-1100-36-ASM
het A @ chr12:21221080


GS06994 - var-GS06994-1100-36-ASM
het A @ chr12:21221080


GS10851 - var-GS10851-1100-36-ASM
het A @ chr12:21221080


GS12004 - var-GS12004-1100-36-ASM
hom A @ chr12:21221080


GS19648 - var-GS19648-1100-36-ASM
het A @ chr12:21221080


GS19649 - var-GS19649-1100-36-ASM
het A @ chr12:21221080


GS19701 - var-GS19701-1100-36-ASM
het A @ chr12:21221080


GS20502 - var-GS20502-1100-36-ASM
het A @ chr12:21221080


Other external references

  • rs11045819
  • [fluvastatin]
    Subjects homozygous for this genotype showed decreased response to fluvastatin

Other in silico analyses

  • NBLOSUM100 score = 4
  • GET-Evidence autoscore = 1

Edit history

Gene search

"GENE" or "GENE A123C":

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