Comparison of 1,317 prostate cancer cases and 1,842 controls was made. Among the combined group of non-hispanic whites & blacks, cases: Arg/Arg: 536, Gln/Arg: 528, Gln/Gln: 150, and controls: Arg/Arg: 831, Gln/Arg: 700, Gln/Gln: 193.
The most dramatic difference would be expected to be between the homozygotes, based on the hypothesis made by Casey et al., but no statistically significant difference can be seen. The authors note that this is consistent with other attempts to replicate the findings of Casey et al.: “Several other studies, including a population-based study conducted in Sweden, have not found an association between the Arg462Gln polymorphism and sporadic prostate cancer [11,14,16]. The strongest evidence for an association …. has been among hereditary prostate cancer cases …. even these associations are somewhat inconsistent [11,13,14].”