Reported by ClinVar to cause hypertrophic cardiomyopathy (https://www.ncbi.nlm.nih.gov/clinvar/variation/42540/). In ClinVar this variant is reported as “pathogenic” by eight sources, including GeneDx, Invitae, the Stanford Center for Inherited Cardiovascular Disease, and the Laboratory for Molecular Medicine (Partners HealthCare).
This last source provided seven publications supporting this classification (https://www.ncbi.nlm.nih.gov/pubmed/20031618,20378854,16199542,15519027,12707239,19574547,18809796). This variant is quite rare according to ExAC data, consistent with the reported disease-causing hypothesis (http://exac.broadinstitute.org/variant/11-47364249-G-A).