Note: This variant has not been sufficiently evaluated by a GET-Evidence editor.
To be considered sufficiently evaluated a variant must have both "variant evidence" and "clinical importance" scores filled in.
Please help improve GET-Evidence by evaluating evidence for this variant!
Insufficiently evaluated pathogenic
(The "insufficiently evaluated" qualifier is assigned automatically based on the above evidence and importance scores.)
Summary of published research, and additional commentary
Xu J, Zheng SL, Komiya A, Mychaleckyj JC, Isaacs SD, Hu JJ, Sterling D, Lange
EM, Hawkins GA, Turner A, Ewing CM, Faith DA, Johnson JR, Suzuki H, Bujnovszky P,
Wiley KE, DeMarzo AM, Bova GS, Chang B, Hall MC, McCullough DL, Partin AW,
Kassabian VS, Carpten JD, Bailey-Wilson JE, Trent JM, Ohar J, Bleecker ER, Walsh
PC, Isaacs WB, Meyers DA. Germline mutations and sequence variants of the
macrophage scavenger receptor 1 gene are associated with prostate cancer risk.
Nat Genet. 2002 Oct;32(2):321-5. Epub 2002 Sep 16. PubMed PMID: 12244320.
Sun J, Hsu FC, Turner AR, Zheng SL, Chang BL, Liu W, Isaacs WB, Xu J.
Meta-analysis of association of rare mutations and common sequence variants in
the MSR1 gene and prostate cancer risk. Prostate. 2006 May 15;66(7):728-37.
PubMed PMID: 16425212.