This study (with all Japanese subjects) concluded that the CILP protein “regulates TGF-beta signaling and that this regulation has a crucial role in the etiology and pathogenesis of LDD”.
In an attempt to confirm the findings of Seki, et al. 2005, two different ethnic cohorts were evaluated to look for evidence of an association between CILP and LDD susceptibility. The results showed “no evidence of association in the Finnish (OR = 1.35, 95% CI 0.97 to 1.87; p = 0.14) or the Chinese (OR = 1.05, 95% CI 0.77 to 1.43; p = 0.71) samples”. The authors concluded that the I395T variant “ is not a major risk factor for symptoms of LDD in Caucasians or in the general population that included individuals with or without symptoms.”