BRAF mutations in general occur in about 3% of patients with lung adenocarcinoma and are more common in smokers. the v600E mutation is significant higher in melanoma patients, but mutations other than V600E are more common in lung cancers.
As stated above, out of 697 patients with lung adenocarcinoma, 18 had mutations in BRAf, 39% of which were G469A mutations; patients with the mutation received only a partial response to adjuvant treatment. The response of this mutation to Braf inhibitors targeted a the common Braf V600E mutation is currently unknown. However, the non-V600E mutations, however, could be targets for other Braf and ERK inhibitors. Cell lines with non-V600E mutations, such H1755 lung cancer cells with the G469A mutations, are resistant to the growth-suppressive effects of PLX4032 ( Vemurafenib). In fact, Braf mutations commonly render tumor resistance to many of the anti-cancer therapies.
B-Raf mutation G469A contributes to the progression of periampullary and ampullary adenomas and carcinomas. These cancers account for 5 % of all Gastrointestinal tumors. The KRAS and the G469A BRAF mutation occur simultaneously in one periampullary adenoma of duodenal origin (DOI 10.1007/s11605-009-0917-4)
It has been speculated that the presence of the CXCR2G354W allele might allow lung adenocarcinoma NCI-H1395 cells to bypass BRAF G469A-induced OIS (oncogene-induced senescence)
From a Braf mutation analysis test: Results showed that this specific mutation is also implicated in non-Hodgkin lymphoma, colorectal cancer, malignant melanoma ( small percentage), thyroid carcinoma, acute lymphoblastoid leukemia, non-small cell lung carcinoma, and adenocarcinoma of lung as previously mentioned. Mutations in BRAF codons 464-469 occur at a general frequency of10% across all these cancers (OMIM BRAF Mutation Analysis – Tumor Code 9000). Cardio-facio-cutaneous (CFC) syndrome has been implicated with eight BRAF mutations, one of which is G469A.
CanPredict: http://strubiol.icr.ac.uk/extra/mokca/aggregate.php?aggregate_id=110 for Computational