Note: This variant has not been sufficiently evaluated by a GET-Evidence editor.
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(APOB Thr98Ile)
Short summary
Irbestartan more effective than atenolol in lowering blood pressure.
Impact
Insufficiently evaluated pharmacogenetic
(The "insufficiently evaluated" qualifier is assigned automatically based on the above evidence and importance scores.)
Inheritance pattern
unknown
Summary of published research, and additional commentary
Bentzen J, Jørgensen T, Fenger M. The effect of six polymorphisms in the Apolipoprotein B gene on parameters of lipid metabolism in a Danish population. Clin Genet. 2002 Feb;61(2):126-34. PubMed PMID: 11940087.
Increased cholesterol levels, association with
Liljedahl U, Lind L, Kurland L, Berglund L, Kahan T, Syvänen AC. Single nucleotide polymorphisms in the apolipoprotein B and low density lipoprotein receptor genes affect response to antihypertensive treatment. BMC Cardiovasc Disord. 2004 Sep 28;4(1):16. PubMed PMID: 15453913; PubMed Central PMCID: PMC524175.
hu025CEA - CGI sample GS01669-DNA_D02 from PGP sample 27316983 het A @ chr2:21263900
hu04FD18 - CGI sample GS00253-DNA_F01_200_37 het A @ chr2:21263900
hu232307 - PGP14 (hu232307) build 36, substitution variants, hu232307 build 36 substitution variants het A @ chr2:21117405
hu241DEA - CGI sample GS01175-DNA_D05 from PGP sample 1205491 het A @ chr2:21263900
hu3CAB43 - CGI sample GS01175-DNA_D03 from PGP sample 27486199 het A @ chr2:21263900
hu4339C0 - CGI sample GS01175-DNA_H01 from PGP sample 94797469 het A @ chr2:21263900
hu43860C - CGI sample GS00253-DNA_A01_200_37 het A @ chr2:21263900
hu6E4515 - PGP15 (hu6E4515) build 37, from CGI var (software ver 1.12.0.47), CGI sample GS000005532 het A @ chr2:21263900
hu72A81D - CGI sample GS01173-DNA_C02 from PGP sample 10366372 het A @ chr2:21263900
hu7A4AD1 - CGI sample GS01669-DNA_C05 from PGP sample 42408046 het A @ chr2:21263900
hu8229AE - CGI sample GS01173-DNA_A07 from PGP sample 96240009 het A @ chr2:21263900
hu92C40A - CGI sample GS01175-DNA_G03 from PGP sample 92527586 hom A @ chr2:21263900
hu92FD55 - CGI sample GS01669-DNA_A04 from PGP sample 08188426 het A @ chr2:21263900
huA0E089 - CGI sample GS01175-DNA_B04 from PGP sample 88590671 het A @ chr2:21263900
huBAAC98 - CGI sample GS01173-DNA_F02 from PGP sample 70008981 het A @ chr2:21263900
huC30901 - CGI sample GS00253-DNA_B01_200_37 het A @ chr2:21263900
huD81F3D - CGI sample GS01173-DNA_D06 from PGP sample 69488604 het A @ chr2:21263900
GS06994 - var-GS06994-1100-36-ASM hom A @ chr2:21117405
GS10851 - var-GS10851-1100-36-ASM hom A @ chr2:21117405
GS12004 - var-GS12004-1100-36-ASM het A @ chr2:21117405
GS19017 - var-GS19017-1100-36-ASM het A @ chr2:21117405
GS19670 - var-GS19670-1100-36-ASM het A @ chr2:21117405
GS19700 - var-GS19700-1100-36-ASM het A @ chr2:21117405
GS19735 - var-GS19735-1100-36-ASM het A @ chr2:21117405
GS19834 - var-GS19834-1100-36-ASM het A @ chr2:21117405
GS20502 - var-GS20502-1100-36-ASM het A @ chr2:21117405
NA12878