APOB T98I - GET-Evidence

Note: This variant has not been sufficiently evaluated by a GET-Evidence editor.

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(APOB Thr98Ile)

Short summary

Irbestartan more effective than atenolol in lowering blood pressure.

Variant evidence
Computational -
Functional -
Case/Control -
Familial -
Clinical importance
Severity -
Treatability -
Penetrance -


Insufficiently evaluated pharmacogenetic

(The "insufficiently evaluated" qualifier is assigned automatically based on the above evidence and importance scores.)

Inheritance pattern


Summary of published research, and additional commentary


Allele frequency

  • A @ chr2:21263900: 24.7% (2653/10758) in EVS
  • A @ chr2:21117404: 18.8% (24/128) in GET-Evidence
  • Frequency shown in summary reports: 24.7% (2653/10758)


Bentzen J, Jørgensen T, Fenger M. The effect of six polymorphisms in the Apolipoprotein B gene on parameters of lipid metabolism in a Danish population. Clin Genet. 2002 Feb;61(2):126-34. PubMed PMID: 11940087.

Increased cholesterol levels, association with

Liljedahl U, Lind L, Kurland L, Berglund L, Kahan T, Syvänen AC. Single nucleotide polymorphisms in the apolipoprotein B and low density lipoprotein receptor genes affect response to antihypertensive treatment. BMC Cardiovasc Disord. 2004 Sep 28;4(1):16. PubMed PMID: 15453913; PubMed Central PMCID: PMC524175.




hu04FD18 - CGI sample GS00253-DNA_F01_200_37
het A @ chr2:21263900






hu43860C - CGI sample GS00253-DNA_A01_200_37
het A @ chr2:21263900










huC30901 - CGI sample GS00253-DNA_B01_200_37
het A @ chr2:21263900



GS06994 - var-GS06994-1100-36-ASM
hom A @ chr2:21117405


GS10851 - var-GS10851-1100-36-ASM
hom A @ chr2:21117405


GS12004 - var-GS12004-1100-36-ASM
het A @ chr2:21117405


GS19017 - var-GS19017-1100-36-ASM
het A @ chr2:21117405


GS19670 - var-GS19670-1100-36-ASM
het A @ chr2:21117405


GS19700 - var-GS19700-1100-36-ASM
het A @ chr2:21117405


GS19735 - var-GS19735-1100-36-ASM
het A @ chr2:21117405


GS19834 - var-GS19834-1100-36-ASM
het A @ chr2:21117405


GS20502 - var-GS20502-1100-36-ASM
het A @ chr2:21117405




Other external references

  • rs1367117
  • [Hypertension]
    [atenolol; irbesartan]
    The APOB:711C>T, C allele was associated with reduction of blood pressure in response to irbesartan treatment but not atenolol treatment.
    Web search results (3 hits -- see all)
  • AceView: Gene:APOB, a comprehensive annotation of human ...
    AceView offers a comprehensive annotation of human, mouse and nematode genes reconstructed by co-alignment and clustering of all publicly available mRNAs and ESTs on ...
  • Cancer Panel Annotation
    2. 21157019. 35. APOB. NM_000384. intron -336. 111. rs1469513. 2. 21171214. 35. APOB. NM_000384 ... NONSYN. T98I (NP_000375) 0.88. 113. rs1800481. 2. 21178862. 35. APOB. NM_000384 ...

Other in silico analyses

  • NBLOSUM100 score = 3
  • GET-Evidence autoscore = 3

Edit history

Gene search

"GENE" or "GENE A123C":

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