AGT M268T - GET-Evidence

Note: This variant has not been sufficiently evaluated by a GET-Evidence editor.

To be considered sufficiently evaluated a variant must have both "variant evidence" and "clinical importance" scores filled in.

Please help improve GET-Evidence by evaluating evidence for this variant!



(AGT Met268Thr)

Short summary


Variant evidence
Computational 3

PolyPhen2: Benign, score 0.000
SIFT: Tolerated 1.00
GVGD: GV 81.08; GD 0.00; Class C0
Variant Effect Predictor (Ensembl):
Mutation Tasting Prediction: Polymorphism, P value: 0.999999; protein features (might be) affected.

Functional -
Case/Control -
Familial -
Clinical importance
Severity -
Treatability -
Penetrance -


Insufficiently evaluated not reviewed

(The "insufficiently evaluated" qualifier is assigned automatically based on the above evidence and importance scores.)

Inheritance pattern


Summary of published research, and additional commentary


Allele frequency

  • G @ chr1:230845794: 56.1% (6039/10758) in EVS
  • G @ chr1:228912416: 44.6% (33/74) in GET-Evidence
  • Frequency shown in summary reports: 56.1% (6039/10758)


301 Moved Permanently

Moved Permanently

The document has moved here.

PubMed PMID: 11731937



hu04FD18 - CGI sample GS00253-DNA_F01_200_37
het G @ chr1:230845794


hu0D879F - CGI sample GS00253-DNA_G01_200_37
hom G @ chr1:230845794


hu0E64A1 - CGI sample GS01173-DNA_B02 from PGP sample 94378523
het G @ chr1:230845794



hu241DEA - CGI sample GS01175-DNA_D05 from PGP sample 1205491
hom G @ chr1:230845794


hu2DBF2D - CGI sample GS01173-DNA_G02 from PGP sample 67180598
hom G @ chr1:230845794



hu342A08 - CGI sample GS01175-DNA_B05 from PGP sample 83494370
het G @ chr1:230845794



hu38168C - CGI sample GS01173-DNA_H06 from PGP sample 91708424
hom G @ chr1:230845794


hu3CAB43 - CGI sample GS01175-DNA_D03 from PGP sample 27486199
het G @ chr1:230845794


hu4040B8 - CGI sample GS01175-DNA_D01 from PGP sample 31286272
het G @ chr1:230845794


hu43860C - CGI sample GS00253-DNA_A01_200_37
het G @ chr1:230845794


hu4CA5B9 - CGI sample GS01669-DNA_B03 from PGP sample 14427241
het G @ chr1:230845794


hu604D39 - CGI sample GS00253-DNA_B02_200_37
het G @ chr1:230845794




hu92C40A - CGI sample GS01175-DNA_G03 from PGP sample 92527586
hom G @ chr1:230845794


hu92FD55 - CGI sample GS01669-DNA_A04 from PGP sample 08188426
hom G @ chr1:230845794


hu9385BA - CGI sample GS00253-DNA_E01_200_37
het G @ chr1:230845794


huA0E089 - CGI sample GS01175-DNA_B04 from PGP sample 88590671
het G @ chr1:230845794


huAE4A11 - CGI sample GS01669-DNA_F02 from PGP sample 40767107
hom G @ chr1:230845794


huB1FD55 - CGI sample GS01173-DNA_B07 from PGP sample 61499538
hom G @ chr1:230845794


huCA017E - CGI sample GS01175-DNA_B01 from PGP sample 86206034
hom G @ chr1:230845794


huD37D14 - CGI sample GS01175-DNA_A04 from PGP sample 13272228
het G @ chr1:230845794


huD81F3D - CGI sample GS01173-DNA_D06 from PGP sample 69488604
hom G @ chr1:230845794


huFFAD87 - CGI sample GS01669-DNA_H05 from PGP sample 10971581
het G @ chr1:230845794


GS18555 - var-GS18555-1100-36-ASM
het G @ chr1:228912417


GS19020 - var-GS19020-1100-36-ASM
hom G @ chr1:228912417


GS19025 - var-GS19025-1100-36-ASM
hom G @ chr1:228912417


GS19026 - var-GS19026-1100-36-ASM
hom G @ chr1:228912417


GS19239 - var-GS19239-1100-36-ASM
hom G @ chr1:228912417


GS19240 - var-GS19240-1100-36-ASM
hom G @ chr1:228912417


GS19703 - var-GS19703-1100-36-ASM
hom G @ chr1:228912417


GS19735 - var-GS19735-1100-36-ASM
hom G @ chr1:228912417


GS19834 - var-GS19834-1100-36-ASM
het G @ chr1:228912417


GS20502 - var-GS20502-1100-36-ASM
het G @ chr1:228912417


Other external references

  • rs699
  • GeneTests records for the AGT gene
    Cardiovascular Disease Risk Factor (Angiotensinogen)
    Hyperoxaluria, Primary, Type 1
  • Score: 0 (benign)
    Web search results (55 hits -- see all)
  • Association of Aldosterone Concentration and ...
    angiotensinogen (AGT) c. 6G>A and p.M268T and mineralocorticoid ... AGT p.M268T, and 61 C for AGT 6G>A), and. extension at 72 C for 1 minute, with a final ...
  • BiomedExperts: Evaluation of angiotensinogen c.1-44G>A and p ...
    'Evaluation of angiotensinogen c.1-44G>A and p.M268T variants as risk factors for fibrosis progression in chronic hepatitis C and liver diseases of various ...
  • Angiotensin II Type 1 Receptor 1166C Polymorphism Is ...
    The AGT 268T allele appeared to have an epistatic effect on large aneurysm size. ... It should be noted that the AGT M268T SNP has previously been misdesignated M235> ...
  • Genetics & Genomics - Study investigated role of ...
    NewsRx is the leading source of news and information on Genetics & Genomics ... angiotensinogen (AGT) carries two common polymorphisms, T207M4 and M268T (previously ...
  • Genetic Analysis of the Angiotensinogen Gene in Pre-Eclampsia ...
    Karger is a medical publisher, scientific publisher and biomedical publisher of print and online journals and books.
  • AceView: Gene:AGT, a comprehensive annotation of human, mouse ...
    AceView offers a comprehensive annotation of human, mouse and nematode genes reconstructed by co-alignment and clustering of all publicly available mRNAs and ESTs on ...
  • Association of aldosterone concentration and ...
    Association of aldosterone concentration and mineralocorticoid receptor genotype ... and angiotensinogen (AGT) c.-6G>A and p.M268T and mineralocorticoid receptor ...
  • Angiotensinogen gene polymophism predicts blood pressure ...
    Four SNPs, -6 A/G, T207M, M268T and C11537A, were selected based on the TagSNP ... a SNP in 3-UTR of the AGT gene is associated with DBP response to ...
  • Medical University, Graz - Study investigated role of ...
    NewsRx is the leading source of news and information on Medical University, Graz ... The AGT Hap2 haplotype was significantly associated with angiotensinogen levels; one ...
  • Fırat Tıp Dergisi
    Anjiyotensinojen için gen, AGT, iki yaygın tek nükleotid polimorfizmi ile karakterize olup T207M ve M268T'dir. ... PCR ile çoğaltılan AGT lokusuna ait fragman Nco1 restriksiyon ...

Other in silico analyses

  • NBLOSUM100 score = 2
  • GET-Evidence autoscore = 3

Edit history

Gene search

"GENE" or "GENE A123C":

Log in