This paper refers to rs5186 according to its position relative to the stop codon in mRNA: 1166. Hypertensive patients had onset less than 60 years, diastolic >95 mmHg on 2 consecutive visits OR long-term treatment, family history of <60 years-of-age hypertension in at least one parent and one sibling. These are compared to a normotensive group, which had to have systolic < 140 mm Hg, diastolic <90 mm Hg and no hypertensive treatment.
Genotypes in normotensive group: AA: 153, AC: 121, CC: 24.
Genotypes in hypertensive group: AA: 84, AC: 95, CC: 27.
Counting allele frequencies, using Fisher’s Exact this has p = 0.011. Based on hypertension incidence of ~28%, these allele frequencies predict ~4% increased attributable risk per allele.