UGT2B7 Y268H - GET-Evidence

Note: This variant has not been sufficiently evaluated by a GET-Evidence editor.

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UGT2B7 Y268H

(UGT2B7 Tyr268His)

You are viewing an old version of this page that was saved on March 29, 2011 at 8:55pm by Genome Importing Robot.

Short summary


Variant evidence
Computational -
Functional -
Case/Control -
Familial -
Clinical importance
Severity -
Treatability -
Penetrance -


Insufficiently evaluated pharmacogenetic

(The "insufficiently evaluated" qualifier is assigned automatically based on the above evidence and importance scores.)

Inheritance pattern


Summary of published research, and additional commentary


Allele frequency

  • C @ chr4:69964338: 20.7% (2230/10756) in EVS
  • TC @ chr4:69998925: 58.5% (69/118) in GET-Evidence
  • Frequency shown in summary reports: 20.7% (2230/10756)


Madadi P, Ross CJ, Hayden MR, Carleton BC, Gaedigk A, Leeder JS, Koren G. Pharmacogenetics of neonatal opioid toxicity following maternal use of codeine during breastfeeding: a case-control study. Clin Pharmacol Ther. 2009 Jan;85(1):31-5. Epub 2008 Aug 20. PubMed PMID: 18719619.



hu034DB1 - CGI sample GS00253-DNA_A02_200_37
het TC @ chr4:69964337


hu04FD18 - CGI sample GS00253-DNA_F01_200_37
het TC @ chr4:69964337


hu0D879F - CGI sample GS00253-DNA_G01_200_37
hom TC @ chr4:69964337



huAE6220 - CGI sample GS00253-DNA_H01_200_37
het TC @ chr4:69964337


GS06985 - var-GS06985-1100-36-ASM
het TC @ chr4:69998926


GS07357 - var-GS07357-1100-36-ASM
het TC @ chr4:69998926


GS12004 - var-GS12004-1100-36-ASM
het TC @ chr4:69998926


GS18501 - var-GS18501-1100-36-ASM
hom TC @ chr4:69998926


GS18502 - var-GS18502-1100-36-ASM
hom TC @ chr4:69998926


GS18504 - var-GS18504-1100-36-ASM
hom TC @ chr4:69998926


GS18505 - var-GS18505-1100-36-ASM
hom TC @ chr4:69998926


GS18508 - var-GS18508-1100-36-ASM
het TC @ chr4:69998926


GS18517 - var-GS18517-1100-36-ASM
hom TC @ chr4:69998926


GS18526 - var-GS18526-1100-36-ASM
het TC @ chr4:69998926


GS18537 - var-GS18537-1100-36-ASM
het TC @ chr4:69998926


GS18555 - var-GS18555-1100-36-ASM
het TC @ chr4:69998926


GS18558 - var-GS18558-1100-36-ASM
het TC @ chr4:69998926


GS18940 - var-GS18940-1100-36-ASM
het TC @ chr4:69998926


GS18942 - var-GS18942-1100-36-ASM
hom TC @ chr4:69998926


GS18947 - var-GS18947-1100-36-ASM
hom TC @ chr4:69998926


GS19017 - var-GS19017-1100-36-ASM
hom TC @ chr4:69998926


GS19020 - var-GS19020-1100-36-ASM
het TC @ chr4:69998926


GS19025 - var-GS19025-1100-36-ASM
het TC @ chr4:69998926


GS19129 - var-GS19129-1100-36-ASM
hom TC @ chr4:69998926


GS19238 - var-GS19238-1100-36-ASM
hom TC @ chr4:69998926


GS19239 - var-GS19239-1100-36-ASM
hom TC @ chr4:69998926


GS19240 - var-GS19240-1100-36-ASM
hom TC @ chr4:69998926


GS19648 - var-GS19648-1100-36-ASM
het TC @ chr4:69998926


GS19649 - var-GS19649-1100-36-ASM
het TC @ chr4:69998926


GS19700 - var-GS19700-1100-36-ASM
hom TC @ chr4:69998926


Added in this revision:

GS19701 - var-GS19701-1100-36-ASM
het TC @ chr4:69998926
























Other external references

  • rs7439366
  • rs7438284
  • [codeine]
    Risk or phenotype-associated allele(s): T/T. Phenotype: Breastfed infants of mothers who are CYP2D6 UMs combined with the UGT2B7*2/*2 are at increased risk of potentially life-threatening CNS depression Study size: 72 mother-child pairs.

Other in silico analyses

  • NBLOSUM100 score = –1
  • GET-Evidence autoscore = 1

Edit history

Gene search

"GENE" or "GENE A123C":

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