TRIB3 Q84R - GET-Evidence

Note: This variant has not been sufficiently evaluated by a GET-Evidence editor.

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(TRIB3 Gln84Arg)

Short summary


Variant evidence
Computational -
Functional -
Case/Control -
Familial -
Clinical importance
Severity -
Treatability -
Penetrance -


Insufficiently evaluated pharmacogenetic

(The "insufficiently evaluated" qualifier is assigned automatically based on the above evidence and importance scores.)

Inheritance pattern


Summary of published research, and additional commentary


Allele frequency

  • G @ chr20:368905: 15.6% (1682/10756) in EVS
  • G @ chr20:316904: 12.9% (16/124) in GET-Evidence
  • Frequency shown in summary reports: 15.6% (1682/10756)


Prudente S, Scarpelli D, Chandalia M, Zhang YY, Morini E, Del Guerra S, Perticone F, Li R, Powers C, Andreozzi F, Marchetti P, Dallapiccola B, Abate N, Doria A, Sesti G, Trischitta V. The TRIB3 Q84R polymorphism and risk of early-onset type 2 diabetes. J Clin Endocrinol Metab. 2009 Jan;94(1):190-6. Epub 2008 Nov 4. PubMed PMID: 18984671; PubMed Central PMCID: PMC2630876.



hu0D879F - CGI sample GS00253-DNA_G01_200_37
het G @ chr20:368905










huAE6220 - CGI sample GS00253-DNA_H01_200_37
het G @ chr20:368905


huBEDA0B - CGI sample GS00253-DNA_C01_200_37
het G @ chr20:368905



GS18526 - var-GS18526-1100-36-ASM
het G @ chr20:316905


GS18942 - var-GS18942-1100-36-ASM
hom G @ chr20:316905


GS19026 - var-GS19026-1100-36-ASM
het G @ chr20:316905


GS19238 - var-GS19238-1100-36-ASM
het G @ chr20:316905


GS19649 - var-GS19649-1100-36-ASM
het G @ chr20:316905


GS19700 - var-GS19700-1100-36-ASM
het G @ chr20:316905


GS20502 - var-GS20502-1100-36-ASM
het G @ chr20:316905


GS21767 - var-GS21767-1100-36-ASM
het G @ chr20:316905


Other external references

  • rs2295490
  • [Diabetes Mellitus, Type 2]
    This variant in the TRIB3 gene is associated with early-onset T2D in Whites. This Q84R "gain of function" polymorphism, impairs insulin signaling.
  • Score: 0 (benign)

Other in silico analyses

  • NBLOSUM100 score = 0
  • GET-Evidence autoscore = 1

Edit history

Gene search

"GENE" or "GENE A123C":

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