TLR6 V465I - GET-Evidence

Note: This variant has not been sufficiently evaluated by a GET-Evidence editor.

To be considered sufficiently evaluated a variant must have both "variant evidence" and "clinical importance" scores filled in.

Please help improve GET-Evidence by evaluating evidence for this variant!


TLR6 V465I

(TLR6 Val465Ile)

Short summary


Variant evidence
Computational -
Functional -
Case/Control -
Familial -
Clinical importance
Severity -
Treatability -
Penetrance -


Insufficiently evaluated not reviewed

(The "insufficiently evaluated" qualifier is assigned automatically based on the above evidence and importance scores.)

Inheritance pattern


Summary of published research, and additional commentary


Allele frequency

  • T @ chr4:38829702: 1.8% (193/10758) in EVS
  • Frequency shown in summary reports: 1.8% (193/10758)



Other external references

  • Score: 0 (benign)
    Web search results (9 hits -- see all)
  • TLR6 Gene - GeneCards | TLR6 Protein | TLR6 Antibody
    EntrezGene summary for TLR6: The protein encoded by this gene is a member of the Toll ... Millipore Mono- and Polyclonal Antibodies for the study of TLR6 ...
  • Toll-like receptor 6 precursor - Homo sapiens (Human)
    TLR6. Organism. Homo sapiens (Human) [Complete proteome] Taxonomic identifier. 9606 [NCBI] ... "TLR6: a novel member of an expanding Toll-like receptor family." Takeuchi O., Kawai T. ...
  • Supplementary Table xls.1
    ... kÇkükékâkäkàkåkçkêkëkèkïkîkìkÄkÅkÉkækÆkôkökòkûkùkÿkÖkÜk¢k£k¥k ... 0;\-"ú"#,##0*"ú"#,##0;[Red]\-"ú"#,##0*"ú"#,##0.00;\-"ú"#,##0.00**#*"ú"#,##0.00; ...
  • Mooney Lab - MutDB
    Mooney Lab Home Publications Research Contact Us. Gene ID: TLR6 ... MutDB MutPred In Silico Functional Profiling PhenoPred S-BLEST CRP Web Services ...
  • SNP Analysis from UTSW
    TLR6. Description. TL receptor 6. Date. 06/07/05. Logfile. log.txt. Download. results.txt ... rs5743816. 55. I/V. 90.8. 35. 142.685714285714. 1717. 1486. G. A. G. G. G. G. A/G ...
  • Table S7.
    TLR6. 1325. D442A. possibly damaging. TLR6. 1393. rs5743816. V465I. benign ... A474T. benign. TLR6. 1421. A474V. benign. TLR6. 1775. rs5743617. G592V. benign. TLR6. 2069 ...
  • UniProt: Q9Y2C9
    Takeda K., Akira S.; RT "TLR6: a novel member of an expanding Toll-like receptor ... GeneCards; GC04M038504; -. DR H-InvDB; HIX0031342; -. DR HGNC; HGNC:16711; TLR6. ...

Other in silico analyses

  • NBLOSUM100 score = –4
  • GET-Evidence autoscore = 2

Edit history

Gene search

"GENE" or "GENE A123C":

Log in