In a study of 389 Japanese individuals with immunoglobulin A nephropathy (IgAN) and 465 controls, this variant was found to associate with disease with an OR of 1.59. This variant is in the secretory component, but biopsies showed no correlation with immunoglobulin A levels.
Case var/var: 24, var/+: 113, /: 252
Cont var/var: 11, var/+: 109, /: 345