This allele is associated with brown/black eyes vs. blue/gray and green/hazel eyes. 9.8% and 11.8% of individuals with blue/gray or green/hazel eyes have one or two copies of this variant, while 21.4% of individuals with brown/black eyes have one or two copies. P value < 0.001 and the highest odds ratio (blue/gray vs brown/black) was 2.48. They also report an association with Arg419Gln and green/hazel eyes vs. blue/gray.
This study looked for and found association of malignant melanoma with variants in OCA2, and this association remains even when other risk factors are taken into account (skin color, eye color, nevus count, etc). This variant did not, however, show any association with malignant melanoma. They confirm that this variant (which they call SNP 5) is associated with dark eye color (p = 0.007). (They do not report a significant association for Arg419Gly, probably because they classified eyes as dark or light, combining both green and blue into a single category.)