Note: This variant has not been sufficiently evaluated by a GET-Evidence editor.
To be considered sufficiently evaluated a variant must have both "variant evidence" and "clinical importance" scores filled in.
Please help improve GET-Evidence by evaluating evidence for this variant!
You are viewing an old version of this page that was saved on December 6, 2010 at 4:24pm by Madeleine Ball.
Edited in this revision:
This variant was weakly associated with a protective effect vs. colorectal cancer, but only in individuals with low alcohol consumption.
p = 0.04
See Ma J et al. 1999 (10498402).
~0.5% decreased risk
Insufficiently evaluated pharmacogenetic
(The "insufficiently evaluated" qualifier is assigned automatically based on the above evidence and importance scores.)
Summary of published research, and additional commentary
Ma J, Stampfer MJ, Christensen B, Giovannucci E, Hunter DJ, Chen J, Willett
WC, Selhub J, Hennekens CH, Gravel R, Rozen R. A polymorphism of the methionine
synthase gene: association with plasma folate, vitamin B12, homocyst(e)ine, and
colorectal cancer risk. Cancer Epidemiol Biomarkers Prev. 1999 Sep;8(9):825-9.
PubMed PMID: 10498402.
hu04FD18 - CGI sample GS00253-DNA_F01_200_37
het G @ chr1:237048500