Note: This variant has not been sufficiently evaluated by a GET-Evidence editor.
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Insufficiently evaluated pharmacogenetic
(The "insufficiently evaluated" qualifier is assigned automatically based on the above evidence and importance scores.)
Summary of published research, and additional commentary
Hughes LB, Beasley TM, Patel H, Tiwari HK, Morgan SL, Baggott JE, Saag KG,
McNicholl J, Moreland LW, Alarcón GS, Bridges SL Jr. Racial or ethnic differences
in allele frequencies of single-nucleotide polymorphisms in the
methylenetetrahydrofolate reductase gene and their influence on response to
methotrexate in rheumatoid arthritis. Ann Rheum Dis. 2006 Sep;65(9):1213-8. Epub
2006 Jan 26. PubMed PMID: 16439441; PubMed Central PMCID: PMC1798268.