A study of patients with suspected immunodeficiency found a higher number of homozygous and compound heterozygous patients with abnormal mannan-binding protein (MBP) alleles (variants B, C, and D). In the case group of 229 patients, one patient was homozygous for D and five were compound heterozygous for B/D. No patients in the control population of 123 controls were homozygous or compound heterozygous for this allele.
Case+: 6, Case-: 223, Control+: 0, Control-: 123. Our 2-tailed Fisher’s Exact test finds this has a p=0.0953.