Note: This variant has not been sufficiently evaluated by a GET-Evidence editor.
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Insufficiently evaluated pathogenic
(The "insufficiently evaluated" qualifier is assigned automatically based on the above evidence and importance scores.)
Summary of published research, and additional commentary
Bray PF, Cannon CP, Goldschmidt-Clermont P, Moyé LA, Pfeffer MA, Sacks FM,
Braunwald E. The platelet Pl(A2) and angiotensin-converting enzyme (ACE) D allele
polymorphisms and the risk of recurrent events after acute myocardial infarction.
Am J Cardiol. 2001 Aug 15;88(4):347-52. PubMed PMID: 11545752.
Undas A, Brummel K, Musial J, Mann KG, Szczeklik A. Pl(A2) polymorphism of
beta(3) integrins is associated with enhanced thrombin generation and impaired
antithrombotic action of aspirin at the site of microvascular injury.
Circulation. 2001 Nov 27;104(22):2666-72. PubMed PMID: 11723016.
Abderrazek F, Chakroun T, Addad F, Dridi Z, Gerotziafas G, Gamra H, Hassine M,
Elalamy I. The GPIIIa PlA polymorphism and the platelet hyperactivity in Tunisian
patients with stable coronary artery disease treated with aspirin. Thromb Res.
2010 Jun;125(6):e265-8. doi: 10.1016/j.thromres.2010.01.011. PubMed PMID: