HTR5A P15S - GET-Evidence

Note: This variant has not been sufficiently evaluated by a GET-Evidence editor.

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(HTR5A Pro15Ser)

Short summary


Variant evidence
Computational -
Functional -
Case/Control -
Familial -
Clinical importance
Severity -
Treatability -
Penetrance -


Insufficiently evaluated not reviewed

(The "insufficiently evaluated" qualifier is assigned automatically based on the above evidence and importance scores.)

Inheritance pattern


Summary of published research, and additional commentary


Allele frequency

  • T @ chr7:154862652: 4.4% (470/10758) in EVS
  • T @ chr7:154493584: 3.2% (4/124) in GET-Evidence
  • Frequency shown in summary reports: 4.4% (470/10758)


Iwata N, Ozaki N, Inada T, Goldman D. Association of a 5-HT(5A) receptor polymorphism, Pro15Ser, to schizophrenia. Mol Psychiatry. 2001 Mar;6(2):217-9. PubMed PMID: 11317225.

Case-control study in a Japanese population with 249 unrelated schizophrenic patients and 253 unrelated controls found an association of Pro15Ser to schizophrenia (P<0.0001).


hu72A81D - CGI sample GS01173-DNA_C02 from PGP sample 10366372
het T @ chr7:154862652


hu8229AE - CGI sample GS01173-DNA_A07 from PGP sample 96240009
het T @ chr7:154862652


huA0E089 - CGI sample GS01175-DNA_B04 from PGP sample 88590671
het T @ chr7:154862652



huAE4A11 - CGI sample GS01669-DNA_F02 from PGP sample 40767107
het T @ chr7:154862652


huE80E3D - CGI sample GS00253-DNA_D01_200_37
het T @ chr7:154862652


GS07357 - var-GS07357-1100-36-ASM
het T @ chr7:154493585


GS19700 - var-GS19700-1100-36-ASM
het T @ chr7:154493585


Other external references

  • rs11575874
  • Score: 0 (benign)

Other in silico analyses

  • NBLOSUM100 score = 3
  • GET-Evidence autoscore = 2

Edit history

Gene search

"GENE" or "GENE A123C":

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