EGFR T790M - GET-Evidence

Note: This variant has not been sufficiently evaluated by a GET-Evidence editor.

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Curation:
Currentness:

EGFR T790M

(EGFR Thr790Met)


Short summary

 

Variant evidence
Computational -
Functional -
Case/Control -
Familial -
 
Clinical importance
Severity -
Treatability -
Penetrance -
 

Impact

Insufficiently evaluated pathogenic

(The "insufficiently evaluated" qualifier is assigned automatically based on the above evidence and importance scores.)

Inheritance pattern

unknown

Summary of published research, and additional commentary

 

Allele frequency

  • None available.

Publications
 

Genomes
 

Other external references
 

    PolyPhen-2
  • Score: 1.0 (probably damaging)
    Web search results (8310 hits -- see all)
  • EGFR-T790M Is a Rare Lung Cancer Susceptibility Allele with ...
    EGFR-T790M Is a Rare Lung Cancer Susceptibility Allele with Enhanced Kinase Activity ... Recently, a report describing EGFR-T790M as a germ-line mutation ...
    cancerres.aacrjournals.org/cgi/content/full/67/10/4665
  • Data Sheet EGFR T790M
    EGFR T790M. human, recombinant, N-terminal GST tag. Catalog #: 40188. Formulated in. 25 mM ... 7 µg EGFR T790M. Lane 2. Protein Marker. BioLabs (#P7708L) Description ...
    www.bpsbioscience.com/pdf/40188.pdf
  • Novel mutant-selective EGFR kinase inhibitors against EGFR T790M.
    Strategies targeting EGFR T790M with irreversible inhibitors have had limited success and are associated with toxicity due to concurrent inhibition of wild-type EGFR. ...
    www.ncbi.nlm.nih.gov/pubmed/20033049
  • EGFR (T790M/L858R) (h)
    Caliper LS ... Site Home > Products and Contract Services > Contract Research > In Vitro > Kinases > EGFR (T790M/L858R) (h) GPCRs. Ion Channels. Transporters. Nuclear Receptors ...
    caliperls.com/products/.../kinases/egfr-t790ml858r-h.htm
  • EGFR (T790M)
    EGFR (T790M) (Epidermal growth factor receptor, Receptor tyrosine-protein kinase ErbB-1) ... Reference Compound IC50 for EGFR (T790M) -10 -9 -8 -7 -6 -5 -4. 0. 20 ...
    www.reactionbiology.com/newcurves070730/EGFR(T790M).pdf
  • EGFR (T790M) (h)
    Caliper LS ... EGFR (T790M) (h) Cat#: 200-0835. Species: Human. Region. Recombinant cells. Enzyme Family. Tyrosine kinase (TK) Substrate. Fluorescein-labeled peptide ...
    caliperls.com/products/.../in-vitro/kinases/egfr-t790m-h.htm
  • Access : Novel mutant-selective EGFR kinase inhibitors ...
    Novel mutant-selective EGFR kinase inhibitors against EGFR T790M ... They are also effective in murine models of lung cancer driven by EGFR T790M. ...
    nature.com/nature/journal/v462/n7276/full/nature08622.html
  • Development of New Mouse Lung Tumor Models Expressing EGFR ...
    The EGFR T790M mutation confers acquired resistance to kinase ... Inducible, lung-specific expression of the mutant EGFR transgene in C/L858R+T790M mice ...
    www.ncbi.nlm.nih.gov/pmc/articles/PMC1950079
  • Novel mutant-selective EGFR kinase inhibitors against EGFR ...
    Strategies targeting EGFR T790M with irreversible inhibitors have had limited success and are associated with toxicity due to concurrent inhibition of wild-type EGFR. ...
    labmeeting.com/paper/29447430/zhou-2009-novel-mutant-selective-egfr...
  • Unbound MEDLINE | Amplification of EGFR T790M causes ...
    Unbound MEDLINE | Amplification of EGFR T790M causes resistance to an irreversible EGFR inhibitor. Journal article. Search by keyword, journal, author or by EBM ...
    unboundmedicine.com/medline/ebm/record/20118985/...

Other in silico analyses
 

  • NBLOSUM100 score = 2
  • GET-Evidence autoscore = 5

Edit history
 

Gene search

"GENE" or "GENE A123C":

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