Associated with thicker hair, common in Chinese and Japanese individuals and thought to be Asian-specific.
C allele (Ala) is associated with larger cross-sectional area in Indonesian sample (p = 5.5 * 10^-3) and Thai-Mai sample (9.5 * 10^-4).
Functional analysis examining the interaction between EDAR and the EDAR-binding death domain adapter protein, EDARADD, which results in activation of NF-kappaB. The C allele showed lower NF-kappaB induced activation of a luciferase reporter, indicating this variant causes lower activity of NF-kappaB.