CYP2C9 R150H - GET-Evidence

Note: This variant has not been sufficiently evaluated by a GET-Evidence editor.

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CYP2C9 R150H

(CYP2C9 Arg150His)

Short summary


Variant evidence
Computational -
Functional -
Case/Control -
Familial -
Clinical importance
Severity -
Treatability -
Penetrance -


Insufficiently evaluated pharmacogenetic

(The "insufficiently evaluated" qualifier is assigned automatically based on the above evidence and importance scores.)

Inheritance pattern


Summary of published research, and additional commentary


Allele frequency

  • A @ chr10:96702066: 2.0% (218/10754) in EVS
  • A @ chr10:96692055: 2.4% (3/126) in GET-Evidence
  • Frequency shown in summary reports: 2.0% (218/10754)


Cavallari LH, Langaee TY, Momary KM, Shapiro NL, Nutescu EA, Coty WA, Viana MA, Patel SR, Johnson JA. Genetic and clinical predictors of warfarin dose requirements in African Americans. Clin Pharmacol Ther. 2010 Apr;87(4):459-64. Epub 2010 Jan 13. PubMed PMID: 20072124.



huAE4A11 - CGI sample GS01669-DNA_F02 from PGP sample 40767107
het A @ chr10:96702066


GS18504 - var-GS18504-1100-36-ASM
het A @ chr10:96692056


GS18517 - var-GS18517-1100-36-ASM
het A @ chr10:96692056


GS19017 - var-GS19017-1100-36-ASM
het A @ chr10:96692056


Other external references

  • rs7900194
  • [Atrial Fibrillation; Pulmonary Embolism; Stroke; Venous Thrombosis]
    Phenotype: In African Americans patients, weekly warfarin dose requirements were lower in those with the CYP2C9*8 allele (34 (30-47) mg; P = 0.023) and the CYP2C9 *2, *3, *5, *6, or *11 allele (33(28-40 mg); P < 0.001) as compared with those with the CYP2C9*1/*1 genotype (43 (35-56) mg). Adding the *5,*6,*8 and *11 alleles to a model containing the *2 and *3 alleles plus the VKORC1 -1639 G>A allele (along with clinical variables) explained 36% vs. 30% of the variability in dose requirements. Study size: 226 . Study population/ethnicity: African-American . Type of association: PD;GN;CO
  • Score: 0 (benign)

Other in silico analyses

  • NBLOSUM100 score = 1
  • GET-Evidence autoscore = 2

Edit history

Gene search

"GENE" or "GENE A123C":

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