CYP1A1 T461N - GET-Evidence

Note: This variant has not been sufficiently evaluated by a GET-Evidence editor.

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CYP1A1 T461N

(CYP1A1 Thr461Asn)

Short summary


Variant evidence
Computational -
Functional -
Case/Control -
Familial -
Clinical importance
Severity -
Treatability -
Penetrance -


Insufficiently evaluated pharmacogenetic

(The "insufficiently evaluated" qualifier is assigned automatically based on the above evidence and importance scores.)

Inheritance pattern


Summary of published research, and additional commentary


Allele frequency

  • T @ chr15:75012987: 3.6% (383/10758) in EVS
  • T @ chr15:72800039: 0.8% (1/128) in GET-Evidence
  • Frequency shown in summary reports: 3.6% (383/10758)



Other external references

  • rs1799814
  • Score: 0.001 (benign)
    Web search results (162 hits -- see all)
  • CYP1A1 [PharmGKB]
    rs1799814 at chr15:72800040 in CYP1A1. Increased risk for smokers to develop gastric ... CYP1A1*4; CYP1A1:T461N; CYP1A1:2453C>A; CYP1A1:4887C>A; CYP1A1:m4 ...
  • CYP1A1
    CYP1A1*4. CYP1A1.4. 2452C>A. m4. T461N. Cascorbi et al., 1996. CYP1A1*5 ... 6. CYP1A1.6. 1635G>T. M331I. Chevalier et al., 2001. CYP1A1*7. 2345_2346insT. 426Frameshift ...
  • Genetic association study of CYP1A1 polymorphisms identifies ...
    ... and CYP1A1*4 (rs1799814 2453C>A Thr461Asn (Exon 7)) using PCR-RFLP methods. CYP1A1*2A and CYP1A1*2C variants ... for CYP1A1 in NSCLC and confirms that CYP1A1 polymorphisms are ...
  • CYP1A1 Gene - GeneCards | CP1A1 Protein | CP1A1 Antibody
    EntrezGene summary for CYP1A1: This gene, CYP1A1, encodes a member of ... CYP1A1 Gene in genomic location: bands according to Ensembl, locations according ...
  • Inhibition of CYP1A1
    Thus, the inhibition of CYP1A1 may be one of the key mechanisms for ... the two allelic variants CYP1A1.2 (Ile462Val) and CYP1A1.4 (Thr461Asn) ...
  • CYP1A1, CYP3A5 and CYP3A7 polymorphisms and testicular cancer ...
    CYP1A1, CYP3A5 and CYP3A7 polymorphisms and testicular cancer susceptibility ... of the CYP1A1*2A (MspI), CYP1A1*2C (I462V), CYP1A1*4 (T461N), CYP3A5*3C (A6986G) ...
  • Genetic association study of CYP1A1 polymorphisms identifies ...
    The CYP1A1*2A and CYP1A1*2C variants were significantly over-represented in ... CYP1A1 haplotypes (in allele order CYP1A1*4, CYP1A1*2C, CYP1A1*2A) CGC and CGT ...
  • Differential metabolism of benzo[a]pyrene and benzo[a]pyrene ...
    CYP1A1.1 exhibited with 10.4 pmol/min/pmol CYP1A1 the greatest total ... the neighboring change of T461N, occurring in CYP1A1.4, is of lesser consequence ...
  • Genotyping Panels, Signetâ„¢ Genotyping Panels, Custom-Mixed ...
    Signetâ„¢ Genotyping Panels are specific multiplexes that detect polymorphisms and gene variants associated with a variety of health and nutritional conditions ...
  • The influence of genetic polymorphisms in Ahr, CYP1A1, CYP1A2 ...
    Variants in Ahr (rs4986826), CYP1A1 (rs1799814), and CYP1A2 (rs2069514) were also, ... Keywords: 1-Hydroxypyrene glucuronide; CYP1A1; CYP1A2; CYP1B1; Ahr; GST; UGT; ...

Other in silico analyses

  • NBLOSUM100 score = 1
  • GET-Evidence autoscore = 3

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Gene search

"GENE" or "GENE A123C":

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