This association study looked for associations between 40 variants and myocardial infarction, including this variant. The case/control genotype counts are: case var/var: 76, case var/+: 481, case : 771, cont var/var: 148, cont var/+: 864, cont : 1093.
These numbers are highly significant when applying Fisher’s Exact test to a dominant hypothesis (p = 3.2e-7) and counting number of alleles in each group (p = 3.1e-6), but not under a recessive hypothesis (p = 0.30). Thus, we treat this as having a dominant effect. Assuming a lifetime risk of MI of 15%, we estimate from these numbers that this variant is associated with an attributable increased risk of 3% (18% total risk).