This variant is reported to have an association with lower HDL cholesterol. The study examined variants in seven genes associated with HDL metabolism. They report p=5.95 * 10^-3 (0.00595) for their validation set with the variant (Table 1).
The authors note “our analysis of all common SNPs in the reverse cholesterol pathway was able to explain only 2.2% of variance of HDL-C level in the DHS population”. Based on figure 1, it looks like each snp allele lowers HDL cholesterol by ~2.5 mg/dl on average. Table 1 lists a regression coefficient of -1.27 — unclear if this in mg/dl units?