AGT M268T - GET-Evidence

Note: This variant has not been sufficiently evaluated by a GET-Evidence editor.

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(AGT Met268Thr)

You are viewing an old version of this page that was saved on March 5, 2012 at 11:56am by Genome Importing Robot.

Short summary


Variant evidence
Computational 3

PolyPhen2: Benign, score 0.000
SIFT: Tolerated 1.00
GVGD: GV 81.08; GD 0.00; Class C0
Variant Effect Predictor (Ensembl):
Mutation Tasting Prediction: Polymorphism, P value: 0.999999; protein features (might be) affected.

Functional -
Case/Control -
Familial -
Clinical importance
Severity -
Treatability -
Penetrance -


Insufficiently evaluated not reviewed

(The "insufficiently evaluated" qualifier is assigned automatically based on the above evidence and importance scores.)

Inheritance pattern


Summary of published research, and additional commentary


Allele frequency

  • G @ chr1:230845794: 56.1% (6039/10758) in EVS
  • G @ chr1:228912416: 44.6% (33/74) in GET-Evidence
  • Frequency shown in summary reports: 56.1% (6039/10758)



hu04FD18 - CGI sample GS00253-DNA_F01_200_37
het G @ chr1:230845794


hu0D879F - CGI sample GS00253-DNA_G01_200_37
hom G @ chr1:230845794


Added in this revision:



hu604D39 - CGI sample GS00253-DNA_B02_200_37
het G @ chr1:230845794



hu9385BA - CGI sample GS00253-DNA_E01_200_37
het G @ chr1:230845794


GS18555 - var-GS18555-1100-36-ASM
het G @ chr1:228912417


GS19020 - var-GS19020-1100-36-ASM
hom G @ chr1:228912417


GS19025 - var-GS19025-1100-36-ASM
hom G @ chr1:228912417


GS19026 - var-GS19026-1100-36-ASM
hom G @ chr1:228912417


GS19239 - var-GS19239-1100-36-ASM
hom G @ chr1:228912417


GS19240 - var-GS19240-1100-36-ASM
hom G @ chr1:228912417


GS19703 - var-GS19703-1100-36-ASM
hom G @ chr1:228912417


GS19735 - var-GS19735-1100-36-ASM
hom G @ chr1:228912417


GS19834 - var-GS19834-1100-36-ASM
het G @ chr1:228912417


GS20502 - var-GS20502-1100-36-ASM
het G @ chr1:228912417


Other external references

  • rs699
  • GeneTests records for the AGT gene
    Cardiovascular Disease Risk Factor (Angiotensinogen)
    Hyperoxaluria, Primary, Type 1
  • Score: 0 (benign)
    Web search results (55 hits -- see all)
  • Association of Aldosterone Concentration and ...
    angiotensinogen (AGT) c. 6G>A and p.M268T and mineralocorticoid ... AGT p.M268T, and 61 C for AGT 6G>A), and. extension at 72 C for 1 minute, with a final ...
  • BiomedExperts: Evaluation of angiotensinogen c.1-44G>A and p ...
    'Evaluation of angiotensinogen c.1-44G>A and p.M268T variants as risk factors for fibrosis progression in chronic hepatitis C and liver diseases of various ...
  • Angiotensin II Type 1 Receptor 1166C Polymorphism Is ...
    The AGT 268T allele appeared to have an epistatic effect on large aneurysm size. ... It should be noted that the AGT M268T SNP has previously been misdesignated M235> ...
  • Genetics & Genomics - Study investigated role of ...
    NewsRx is the leading source of news and information on Genetics & Genomics ... angiotensinogen (AGT) carries two common polymorphisms, T207M4 and M268T (previously ...
  • Genetic Analysis of the Angiotensinogen Gene in Pre-Eclampsia ...
    Karger is a medical publisher, scientific publisher and biomedical publisher of print and online journals and books.
  • AceView: Gene:AGT, a comprehensive annotation of human, mouse ...
    AceView offers a comprehensive annotation of human, mouse and nematode genes reconstructed by co-alignment and clustering of all publicly available mRNAs and ESTs on ...
  • Association of aldosterone concentration and ...
    Association of aldosterone concentration and mineralocorticoid receptor genotype ... and angiotensinogen (AGT) c.-6G>A and p.M268T and mineralocorticoid receptor ...
  • Angiotensinogen gene polymophism predicts blood pressure ...
    Four SNPs, -6 A/G, T207M, M268T and C11537A, were selected based on the TagSNP ... a SNP in 3-UTR of the AGT gene is associated with DBP response to ...
  • Medical University, Graz - Study investigated role of ...
    NewsRx is the leading source of news and information on Medical University, Graz ... The AGT Hap2 haplotype was significantly associated with angiotensinogen levels; one ...
  • Fırat Tıp Dergisi
    Anjiyotensinojen için gen, AGT, iki yaygın tek nükleotid polimorfizmi ile karakterize olup T207M ve M268T'dir. ... PCR ile çoğaltılan AGT lokusuna ait fragman Nco1 restriksiyon ...

Other in silico analyses

  • NBLOSUM100 score = 2
  • GET-Evidence autoscore = 3

Edit history

Gene search

"GENE" or "GENE A123C":

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