Note: This variant has not been sufficiently evaluated by a GET-Evidence editor.
To be considered sufficiently evaluated a variant must have both "variant evidence" and "clinical importance" scores filled in.
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Insufficiently evaluated pathogenic
(The "insufficiently evaluated" qualifier is assigned automatically based on the above evidence and importance scores.)
Summary of published research, and additional commentary
Wechsler ME, Lehman E, Lazarus SC, Lemanske RF Jr, Boushey HA, Deykin A, Fahy
JV, Sorkness CA, Chinchilli VM, Craig TJ, DiMango E, Kraft M, Leone F, Martin RJ,
Peters SP, Szefler SJ, Liu W, Israel E; National Heart, Lung, and Blood
Institute's Asthma Clinical Research Network. beta-Adrenergic receptor
polymorphisms and response to salmeterol. Am J Respir Crit Care Med. 2006 Mar
1;173(5):519-26. Epub 2005 Dec 1. PubMed PMID: 16322642; PubMed Central PMCID:
Bleecker ER, Postma DS, Lawrance RM, Meyers DA, Ambrose HJ, Goldman M. Effect
of ADRB2 polymorphisms on response to longacting beta2-agonist therapy: a
pharmacogenetic analysis of two randomised studies. Lancet. 2007 Dec
22;370(9605):2118-25. Review. PubMed PMID: 18156033.