ADRB2 R16G - GET-Evidence

Note: This variant has not been sufficiently evaluated by a GET-Evidence editor.

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(ADRB2 Arg16Gly)

Short summary


Variant evidence
Computational -
Functional -
Case/Control -
Familial -
Clinical importance
Severity -
Treatability -
Penetrance -


Insufficiently evaluated pathogenic

(The "insufficiently evaluated" qualifier is assigned automatically based on the above evidence and importance scores.)

Inheritance pattern


Summary of published research, and additional commentary


Allele frequency

  • None available.


Wechsler ME, Lehman E, Lazarus SC, Lemanske RF Jr, Boushey HA, Deykin A, Fahy JV, Sorkness CA, Chinchilli VM, Craig TJ, DiMango E, Kraft M, Leone F, Martin RJ, Peters SP, Szefler SJ, Liu W, Israel E; National Heart, Lung, and Blood Institute's Asthma Clinical Research Network. beta-Adrenergic receptor polymorphisms and response to salmeterol. Am J Respir Crit Care Med. 2006 Mar 1;173(5):519-26. Epub 2005 Dec 1. PubMed PMID: 16322642; PubMed Central PMCID: PMC2662935.


Bleecker ER, Postma DS, Lawrance RM, Meyers DA, Ambrose HJ, Goldman M. Effect of ADRB2 polymorphisms on response to longacting beta2-agonist therapy: a pharmacogenetic analysis of two randomised studies. Lancet. 2007 Dec 22;370(9605):2118-25. Review. PubMed PMID: 18156033.



Other external references

  • [Asthma; Heart Diseases]
    This variant has been studied in terms of asthma and its drug response and in terms of heart disease and vascular phenotypes and their drug responses.
  • [Asthma]
    [budesonide; fluticasone propionate; formoterol; salmeterol]
    The ADRB2:Arg16Gly variant was not associated with asthma exacerbation in patients treated with inhaled corticosteroids plus longacting beta agonists.
  • [Asthma]
    Relative to ADRB2:16Gly/Gly patients with asthma, ADRB2:16Arg/Arg patients with asthma may have an impaired therapeutic response to salmeterol in either the absence or presence of concurrent inhaled corticosteroid use.

Other in silico analyses

  • NBLOSUM100 score = 6
  • GET-Evidence autoscore = 4

Edit history

Gene search

"GENE" or "GENE A123C":

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