ADRB1 G389R - GET-Evidence

Note: This variant has not been sufficiently evaluated by a GET-Evidence editor.

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(ADRB1 Gly389Arg)

Short summary

Better outcome from treatment with atenolol vs. verapamil.

Variant evidence
Computational -
Functional -
Case/Control -
Familial -
Clinical importance
Severity -
Treatability -
Penetrance -


Insufficiently evaluated pharmacogenetic

(The "insufficiently evaluated" qualifier is assigned automatically based on the above evidence and importance scores.)

Inheritance pattern


Summary of published research, and additional commentary


Allele frequency

  • C @ chr10:115805056: 68.1% (6931/10184) in EVS
  • Frequency shown in summary reports: 68.1% (6931/10184)


Geese WJ, Achanzar W, Rubin C, Hariharan N, Cheng P, Tomlinson L, Ordway N, Dracopoli NC, Delmonte T, Hui L, Krishnan B, Cosma G, Ranade K. Genetic and gene expression studies implicate renin and endothelin-1 in edema caused by peroxisome proliferator-activated receptor gamma agonists. Pharmacogenet Genomics. 2008 Oct;18(10):903-10. PubMed PMID: 18794727.



hu025CEA - CGI sample GS01669-DNA_D02 from PGP sample 27316983
het C @ chr10:115805056


hu0E64A1 - CGI sample GS01173-DNA_B02 from PGP sample 94378523
het C @ chr10:115805056



hu2D6140 - CGI sample GS01173-DNA_F06 from PGP sample 64191565
hom C @ chr10:115805056


hu2DBF2D - CGI sample GS01173-DNA_G02 from PGP sample 67180598
het C @ chr10:115805056



hu34D5B9 - hu34D5B9 exome
het C @ chr10:115805056


hu4339C0 - CGI sample GS01175-DNA_H01 from PGP sample 94797469
het C @ chr10:115805056


hu72A81D - CGI sample GS01173-DNA_C02 from PGP sample 10366372
het C @ chr10:115805056


hu7A4AD1 - CGI sample GS01669-DNA_C05 from PGP sample 42408046
hom C @ chr10:115805056


hu92C40A - CGI sample GS01175-DNA_G03 from PGP sample 92527586
hom C @ chr10:115805056


huAE4A11 - CGI sample GS01669-DNA_F02 from PGP sample 40767107
hom C @ chr10:115805056


huD81F3D - CGI sample GS01173-DNA_D06 from PGP sample 69488604
het C @ chr10:115805056




Other external references

  • rs1801253
  • [Diabetes Mellitus; Edema; Hyperlipidemias]
    The G/G (Gly/Gly) genotype of this SNP was associated with reduced risk of edema resulting from treatment with muraglitazar (BMS-298585) relative to the C/C (Arg/Arg) genotype. The test population consisted of patients with diabetes or hyperlipidemia.

Other in silico analyses

  • NBLOSUM100 score = 6
  • GET-Evidence autoscore = 1

Edit history

Gene search

"GENE" or "GENE A123C":

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